Biochemistry

Question: Comp ar the mechanisms of action of the following 3 enzymes: i) pyruvate dehydogenase ii) isocitrate dehydrogenase iii) alphaketo glutarate dehydrogenase. resolution role: Enzymes are substances that act as a gas pedal to formulate under ones skin about a dilate biochemical reaction. Each enzyme is specific to various reactions. Pyruvate dehydogenase (from Carbohydrate Catabolism) ,isocitrate dehydrogenase (from the Krebs day-after-day round),and alphaketo glutarate dehydrogenase (from the Krebs Cycle) are three of some(prenominal) enzymes whose mechanisms impart be discussed. Pyruvate and acetyl radical radical CoA are important metabolites at the crossing of many carbon-metabolising roadways. In order for pyruvate to be converted to acetyl Coa, aerophilous decarboxylation needs to take place. The enzyme that drives this reaction is pyruvate dehydogenase. Pyruvate dehydrogenase is known as the origin component enzyme of the pyruvate dehydrogenase ha rd (PDC). Pyruvate dehydrogenase is a complex enzyme consisting of four-fold copies of three subunits E1-Pyruvate dehydrogenase ,E2-Dihydrolipoyl transacetylase ,E3-Dihydrolipoyl dehydrogenase .This complex aids in trans scoreing pyruvate into acetyl-CoA(used in the Krebs cycle for respiration purposes) by pyruvate decarboxylation.

Pyruvate dehydrogenase(Pdh) therefore links the glycolysis metabolic pathway to the kreb cycle psychotherapeutic energy via NADH. Pdh is regulated by 4 reversible, inhibitory kinases of E1. The kinases grant differing tissue specificities. The kinases are activated by increa sing the ratios of: [NADH]/[NAD],[acetyl CoA! ],[ATP]/[ADP]. The kinases are inhibited by pyruvate.Insulin stimulates dephosphorylyation.  This is reversed by pyruvate dehydrogenase phosphatase. Pyruvate dehydrogenase phosphatase is stimulated by insulin, PEP, and AMP, but competitively inhibited by ATP, NADH, and Acetyl-CoA. The ylide resonance form of thiamine pyrophosphate (TPP) begins by attacking the electrophilic ketone of pyruvate. The mediate ?-alkoxide...If you want to get a full essay, order it on our website: OrderCustomPaper.com

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