Tau Protein

ROLE OF MICROTUBULE ASSOSCIATED PROTEIN TAU IN BREAST CANCER MICROTUBULE ASSOSCIATED PROTEINS (MAPs) Microtubules represent cardinal of the graphic symbol systems of the eukaryotic cytoskeleton. They consist of a affectionateness cylinder reinforced with polymers of alpha- and beta-tubulin heterodimers, forming tube-shaped filaments, with (?) and (+) endings. Three main classes of proteins interact with tubulin. Microtubules, with their dynamic nature, eonian growing and shortening, caused by the GTP-dependent association and dissociation of the heterodimers at the twain ends, are the crucial organelle during cubicle division. Microtubule-associated proteins (MAP) are wedded to the microtubule-organizing centre (MTOC). Some of them stimulate microtubules organise (MAP2, MAP4, Tau, STOP, Mip-90 and statmin), other chant microtubule space arrangement (MAP1, MAP2 and Tau) or unavailing the organelle migration among microtubules (kinesin, dynein and dynamin) The Microtub ule-associated proteins, or MAPs, are sometimes called more specifically structural MAPs because they bind to, stabilize and promote the assembly of microtubules, and because they can be copurified with tubulin through several(prenominal) cycles of microtubule assembly and disassembly.

FUNCTIONS They are essential for a childlike pastiche of boothular functions, notably cell motility, intracellular transport, charge of cell shape and polarity, cell signaling and mitosis. They form mitotic mandrel that transports fille chromosomes to separate poles of the dividing cell. SIGNIFICANCE Recently, attention has been given to microtubule-associated proteins (MAPs) a! s predictors of chemotherapy sensitivity and patient role relapse. MAPs function throughout the cell cycle to modulate microtubule dynamics. And that is why the anti-microtubule agents inhibit cancer cells multiplication. MAPs pee powerful implications for chemotherapy efficacy and metastatic progression. WHAT IS TAU? TAU is a microtubule-associated protein (MAPs) and located...If you want to get a full essay, set it on our website: OrderCustomPaper.com

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